If the Design Layout is changed but not (yet) saved, an asterix (*) will be shown next to the Design Layout name in the toolbar.
If the Design Layout you edited is a Standard Design Layout, you will get the option to save it as a copy in the Local database when you try to save it.
If you do not want to keep the changes you made, you can Revert to the saved version of the Design Layout, or you can simply deactivate it.
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